Sleepless Over Sinuses

Sleep disorders: sleepless in Singapore.

Sleep disorders are common afflictions in both the paediatric and adult populations, increasingly recognised as major public health concerns. Recently, the Institute of Medicine (USA) convened an ad hoc committee of experts in public health, academic and medical administration, and health sciences research to address sleep health issues, including the impact of sleep loss and sleep disorders on...

Sleepless in the surgical ward.

Sleepless in Seattle No Longer

In enterprise networks, idle desktop machines rarely sleep, because users (and IT departments) want them to be always accessible. While a number of solutions have been proposed, few have been evaluated via real deployments. We have built and deployed a lightweight sleep proxy system at Microsoft Research. Our system has been operational for six months, and has over 50 active users. This paper f...

Identification of SLEEPLESS, a sleep-promoting factor.

Sleep is an essential process conserved from flies to humans. The importance of sleep is underscored by its tight homeostatic control. Through a forward genetic screen, we identified a gene, sleepless, required for sleep in Drosophila. The sleepless gene encodes a brain-enriched, glycosylphosphatidylinositol-anchored protein. Loss of SLEEPLESS protein caused an extreme (>80%) reduction in sleep...

Chronic, draining perianal sinuses.

Photo Quiz Chronic, Draining Perianal Sinuses NEELOFER SOHAIL, M.D., and JEANNE P. SPENCER, M.D., Conemaugh Memorial Hospital, Johnstown, Pennsylvania RENEE MATHER, M.D., Mathur Health Care, Johnstown, Pennsylvania A 46-year-old man with a history of alcohol abuse and hemorrhoids presented with a perianal and perineal rash of three to four weeks' duration. It was associated with severe tenderne...